Project Format Proposal
Infographics were used as the main format for the project on Marfan syndrome because it is a useful tool for presenting information clearly and concisely. The slides use different infographic ideas and patterns to make the information easier to perceive and analyze. Visualizing the statistics and other data will help the audience to memorize the most important and useful facts about the syndrome and apply them in further work and research.
Annotation Citation One
De la Fuente-Alonso, A., Toral, M., Alfayate, A., Ruiz-Rodríguez, M. J., Bonzón-Kulichenko, E., Teixido-Tura, G., Martínez-Martínez, S., Méndez-Olivares, M. J., López-Maderuelo, D., González-Valdés, I., Garcia-Izquierdo, E., & Mingo, S. (2021). Aortic disease in Marfan syndrome is caused by the overactivation of sGC-PRKG signaling by NO. Nature Communications, 12(1). Web.
This article is a reliable source because it has been recently published in a peer-reviewed scientific journal and is licensed under a Creative Commons Attribution 4.0 International License. The findings of the article demonstrate that a significant increase in nitric oxide can be sufficient to induce aortopathy. The plasma of Marfan patients has been shown to have higher levels of nitrated proteins. This research was chosen because it provides important findings to identify biomarkers that will potentially allow more efficient monitoring of Marfan syndrome.
Annotation Citation Two
Pyeritz, R. E. (2019). Marfan syndrome: Improved clinical history results in expanded natural history. Genetics in Medicine, 21(8), 1683-1690. Web.
The source is credible and evidence-based since it is an official journal published by the American College of Medical Genetics and Genomics. Many organ systems and symptoms are only beginning to be recognized in relation to Marfan syndrome. Some examples include the central nervous system, the distal aorta, sleep apnea, etc. Although the life span of people with Marfan syndrome has improved significantly in recent years, it is extremely important to consider these factors when developing treatment and medical assessment procedures. The source will support the project by providing valuable findings on the ways to evaluate different factors and conditions related to Marfan syndrome and its diagnosis.
Annotation Citation Three
Teixido-Tura, G., Forteza, A., Rodríguez-Palomares, J., González Mirelis, J., Gutiérrez, L., Sánchez, V., Ibáñez, B., García-Dorado, D., & Evangelista, A. (2018). Losartan versus Atenolol for prevention of aortic dilation in patients with Marfan syndrome. Journal of the American College of Cardiology, 72(14), 1613-1618. Web.
This source is highly reliable because it is a peer-reviewed American College of Cardiology medical journal. The article provides important findings by assessing the benefit of losartan in comparison to atenolol to successfully prevent aortic dilation and other conditions associated with Marfan syndrome. Factors such as age, baseline aortic root diameter, or type of dominant negative versus haploinsufficient FBN1 mutation are taken into consideration and analyzed. These findings are valuable for the project because they demonstrate that losartan can be used as an alternative to higher-risk beta-blockers in Marfan syndrome management.